Latest episodes 5,556 total
June 12
‘Hard Fork’ Live, Part 1: Satya Nadella and Cindy Cohn
This week and next, we’re bringing you recordings from our second-ever live taping in San Francisco. First, we sit down with Microsoft’s chief executive, Satya…
Claude Fable 5 Broke The AI Industry. Here's What Happens Next.
Huge AI News as we go hands on with Anthropic's Claude Fable 5, the most powerful AI model ever released. Spoiler: We found it very good. What happens next? Thi…
How Enterprise Leaders Should Measure the ROI of AI - with Darko Todorovic of HTEC
Enterprise AI investments frequently succeed at the pilot stage and collapse at scale, not because the technology fails, but because the organizational conditio…
All-In's Best Ideas Pitch Competition: 4 Investors Present Their Top Trades Live
(0:00) Chamath explains the Best Ideas format (2:31) Suvretta Capital Management's Aaron Cowen pitches MGM Resorts (13:07) Bornite Capital's Dan Dreyfus pitches…
June 11
Why Fable 5 Is the Most Controversial AI Release Ever
Fable 5 has become the most controversial AI launch yet, as Anthropic’s safety restrictions, data retention policy, and silent limits on AI development triggere…
The Four Biggest Stories in Tech
Happy Thursday.We’re live on YouTube and 𝕏.The current thing in tech and business is America’s four-year trucking slump is over.Today’…
June 10
Fable 5 Raises the Bar for AI Ambition
Anthropic’s Fable 5 is a major leap in frontier AI, but the bigger shift is what it asks of users: less prompting for small tasks, more imagination about what c…
Senators John Fetterman and Dave McCormick: Bipartisanship, Money in DC, Datacenters, Graham Platner
(0:00) PA Senators Fetterman and McCormick join the Besties (0:33) Bipartisanship in 2026, rejecting extremism (6:37) All-time unpopularity in the Senate, the f…
Facebook gets a Movie, Anthropic gets a Fable
Happy Wednesday.We’re live on YouTube and 𝕏.The current thing in tech and business is the SpaceX IPO will turn 4,400 employees into millionaires.T…
How Mistral Is Building Frontier AI for the Enterprise | NVIDIA AI Podcast Ep. 301
Open-weight models are closing the gap with proprietary AI — and Timothée Lacroix, cofounder and CTO of Mistral, has been betting on that since day one. In this…
Modernizing Targeting to Close the Field Execution Gap - with Damion Nero of Daiichi Sankyo
Pharma commercial teams are generating more data than ever, but field intelligence is still arriving too late to change rep behavior before the engagement windo…
Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
Biohub started with an ambitious goal of curing, preventing, and managing all disease by the end of the century. A decade later, thanks to the convergence of fr…
Claude Fable 5 Is Incredible. And A Little Scary.
Anthropic just released Claude Fable 5, the first public Mythos-class model and the start of the Claude 5 family. It is their most capable model ever but… kinda…
How Unified Context Turns AI Into Real Enterprise Performance - with Ravi Marwaha of Arango
Enterprise AI agents fail consistently in production, not because of model limitations, but because they lack a live, temporally aware context layer grounded in…
Dan Dreyfus: America's Critical Minerals Crisis is Here
(0:00) Dan Dreyfus Presents: The Future of Critical Minerals (0:33) America's "Capital Light Era" is over, rapid supply/demand shocks (5:40) Impact of China cut…
June 9
OpenAI Declares the Next Phase of AI
OpenAI says it is entering a new phase focused on automated AI research, broad access, and turning frontier capability into tools people can actually use. But t…
Reactions to WWDC: Day 1
Happy Tuesday.We’re live on YouTube and 𝕏.The current thing in tech and business is the U.S. expands its list of Chinese tech companies it says as…
Bill Maris: How Google Could Crush AI Competitors, Why Small Funds Win, and AI's Atari Stage
(0:00) Bill Maris joins the Besties! (0:33) Four critical lessons from a career in technology (5:58) Building Google Ventures with data and machine learning (9…
AI Models as a Commodity and Why Data Foundations Decide Who Wins - with Guillermo B. Vazquez of SAP
Enterprise leaders face a growing gap between rapid AI advancement and the fragmented data and processes that limit their ability to operationalize it. In this…
June 8
How We Use AI Is Changing
ChatGPT’s rumored “super app” overhaul isn’t just an IPO story — it’s a sign that AI use is shifting from chat to agents, coding tools, and loops. The result is…
Nikesh Arora: Mythos is Real, Analytical SaaS is Dead, and Google can be a $10T company
(0:00) Palo Alto Networks CEO Nikesh Arora joins the Besties! (0:47) Claude Mythos found years of vulnerabilities in Palo Alto's code in weeks (5:15) Are cyber…
All Eyes on Apple
Happy Monday.We’re live on YouTube and 𝕏.The current thing in tech and business is Cloudflare’s Matthew Prince accusing Khosla Ventures of s…
From Overwhelm to Working AI in Pharma and Life Sciences - with Art Shectman of Elephant Ventures
Regulatory volatility, scientific‑grade context requirements, and entrenched legacy processes are creating a level of operational complexity in pharma that make…
June 7
Inside the Private Stock Market Boom: SpaceX, Anthropic, OpenAI & the Rise of Secondaries
(0:00) Brad Gerstner, Gavin Baker, and Kelly Rodriques join the Besties! (0:47) Secondary Markets are Booming & Competing with IPOs (3:10) Why Companies are Sta…
10+ Things You Should Build With AI Instead of Sending Files
AI is making it possible to build richer versions of the files knowledge workers send every day: decks, memos, spreadsheets, reports, proposals, training materi…
June 6
This Week in AI for Ridiculously Busy People
A fast, five-minute briefing for people who need to know what mattered in AI this week without taking on the full firehose. This week: token efficiency became t…
The IPO Comeback: Why Tech Giants Are Finally Going Public | All-In Liquidity IPO Panel
(0:00) CEOs Andrew Feldman (Cerebras) and Will Marshall (Planet Labs) join the Besties! (2:05) Both CEOs on going public: Impact on employees, customers, and bu…
Every Enterprise Is About to Have a 100,000 Agent Problem | Oren Michaels of Barndoor AI
AI agents can now connect to every tool your employees use. The problem is that connecting them and trusting them are two completely different things, and most…
#247 - Opus 4.8, MAI, Anthropic IPO, Minimax-M3
Our 247th episode with a summary and discussion of last week's big AI news!Recorded on 06/03/2026Hosted by Andrey Kurenkov and Jeremie HarrisFeel free to email…
