Latest episodes 5,558 total
April 8
Josh Shapiro on Trump, Iran War Chaos, Israel's Failure, the Economy, and 2028 Race
(0:00) Jason intros PA Governor Josh Shapiro (1:40) Shapiro's blueprint for PA: pro-growth, pro-freedom, less red tape, prosecuting fraud (13:05) Wealth tax deb…
Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon
Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler, about why Git's user interface has barely changed since 2005, how GitButler i…
Anthropic's Mythos AI Is Too Dangerous to Release. They're Using It Anyway.
Anthropic revealed Mythos, a new AI model so powerful they won't let the public use it. Instead, they're deploying it to defend against cyberattacks with Projec…
Connecting Forecasting and Warehouse Decisions at Scale - with Jerod Hamilton of Tyson Foods
Operational complexity in modern distribution centers is accelerating faster than most organizations can adapt, leaving leaders with fragmented data, static fac…
OpenAI's New Deal
OpenAI released a sweeping policy document proposing everything from public wealth funds to portable benefits — but without a single commitment that would cost…
April 7
Four AI Stories We’re Paying Attention to Today
Happy Tuesday.We’re live on YouTube and 𝕏.The current thing in tech and business is Anthropic’s announcement that it’s now doing $30B…
Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
We’re proud to release this ahead of Ryan’s keynote at AIE Europe. Hit the bell, get notified when it is live! Attendees: come prepped for Ryan’s AMA with Vibhu…
Michael Nielsen – How science actually progresses
Really enjoyed chatting with Michael Nielsen about how we recognize scientific progress.It's especially relevant for closing the RL verification loop for scient…
Decentralized Trials That Scale Globally Without Compliance Risks - with Emma Vitalini of Amgen
Today's guest is Emma Vitalini, Head of Global Digital Health Technology Innovation at Amgen. Amgen is a global biotechnology company focused on discovering, de…
April 6
#330 Sebastian Risi: Why AI Should Be Grown, Not Trained
AI has been trained like software. But what if it should be grown like life? In this episode of Eye on AI, Craig Smith sits down with Sebastian Risi, professor…
The Calm Before the AGI Storm
Even during a relatively quiet week in AI, the signals are unmistakable — every major lab is jostling for position ahead of what feels like a dramatic accelerat…
Lessons From the First Billion Dollar 1-Person Company
Happy Monday.We’re live on YouTube and 𝕏.The current thing in tech and business is Citrini Research sending analysts to the Strait of Hormuz in a…
The Companies Changing Warfare Forever: Palantir & Anduril Execs on Drones, AI & the Future of War
(0:00) Friedberg Intros Palantir's Shyam Sankar and Anduril's Trae Stephens (0:56) Palantir Origins: CIA Analyst Joins 20-Person Startup (2:54) War, Deterrence…
#239 - RIP Sora, Claude Openclaw, HyperAgents
Our 239th episode with a summary and discussion of last week's big AI news!FYI: this one has pretty out of date news, I was traveling last week and failed to up…
Solving the Expertise Gap with AI in Manufacturing - with Antoine Bisson of Poka
Aging expertise, paper‑based instructions, and inconsistent onboarding are creating a widening execution gap on the factory floor as experienced workers retire…
April 5
April 4
April 3
SpaceX IPO, Iran War Fallout, Quantum Bitcoin Hack, The Space Opportunity
(0:00) Bestie intros! (0:12) SpaceX IPO, the economic opportunity of space: a new industrial frontier (21:00) 2026 IPO explosion, OpenAI down round? (36:33) Ira…
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
Fresh off raising a monster $15B, Marc Andreessen has lived through multiple computing platform shifts firsthand, from Mosaic and Netscape to cofounding A16z. I…
How to Build a Personal Context Portfolio and MCP Server
In today's Build episode, we tackle one of the most underappreciated friction points in the agentic era — the fact that every new agent, project, or tool re…
The Future of Addictive Design + Going Deep at DeepMind + HatGPT
Last week, two separate juries held social media companies liable for harming young users. We unpack what these landmark decisions mean — not only for the futur…
Two People Vibe Coded a $1.8B Company. The AI Hard Takeoff Is Here.
Can you vibe code a $1.8 billion company with AI? Sam Altman predicted the one-person billion-dollar startup, and with MedVi, it might've just happened. Today o…
AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
What happens when you apply the scaling laws of large language models to the physical work of atoms? Elad Gil sits down with Liam Fedus, co-founder at Periodic…
April 2
OpenAI acquires TBPN
Today, we’re announcing that OpenAI has acquired TBPN.As part of the acquisition, OpenAI will scale and support TBPN as a platform for live conversations…
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
We’ve been on a bit of a mini World Models series over the last quarter: from introducing the topic with Yi Tay, to exploring Marble with World Labs’ Fei-Fei Li…
Agent Skills Masterclass
Nufar Gaspar walks NLW through a five-level framework for agent skills — from understanding what they are to building an organizational skill library. We get in…
How Digital K‑1 Data Changes Tax Workflow Maturity - with Ken Powell and Neal Schneider
Tax processes remain constrained by document-based workflows that limit data accessibility, speed, and cross-system integration. In this episode, Neal Schneider…
April 1
The Most Extensively Documented Spaceflight in History
Happy Wednesday.We’re live on YouTube and 𝕏.The current thing in tech and business is the Artemis II mission, which is scheduled to launch 4 astro…
Introducing Maturity Maps — A New Way to Measure AI Adoption
Today we're introducing Maturity Maps, a new framework for benchmarking AI and agent adoption across six key dimensions - from deployment depth to systems i…
How AI Is Reshaping IT Services from the Inside
Joe Schmidt speaks with Peter Doyle, CEO of Treeline, about why the $100B managed service provider market is a decade behind modern technology and how Treeline…