Latest episodes 5,559 total
October 19, 2025
5 Prompting Tricks to Make Your AI Less Average
AI is trained on the sum total of human output—which means it often produces the average of averages. That’s fine for passable results, but not for unique, high…
#295 Fergal Reid: Why Your Bots Fail and How Agents Fix Your Customer Support
This episode is sponsored by AGNTCY. Unlock agents at scale with an open Internet of Agents. Visit https://agntcy.org/ and add your support. Why do so many chat…
October 18, 2025
How to Build an AI-Ready Culture: A Practical Guide
In this special Operator’s Cut bonus edition, NLW kicks off a new three-part Agent Readiness series with Superintelligent Head of Research, Nufar Gaspar. Drawin…
The Secret Engine of AI - Prolific [Sponsored] (Sara Saab, Enzo Blindow)
We sat down with Sara Saab (VP of Product at Prolific) and Enzo Blindow (VP of Data and AI at Prolific) to explore the critical role of human evaluation in AI d…
October 17, 2025
Trump: Send National Guard to SF, China Rare Earths Trade War, AI's PR Crisis
(0:00) Bestie intros! Dreamforce and another interesting conference take the Bay Area (3:35) State of crime in SF, do they need the National Guard? (20:48) US t…
15 Business Model Questions for OpenAI and Anthropic
This episode explores the massive revenue growth of OpenAI and Anthropic and what it means for their business models. With Anthropic hitting a $7 billion revenu…
Andrej Karpathy — AGI is still a decade away
The Andrej Karpathy episode.During this interview, Andrej explains why reinforcement learning is terrible (but everything else is much worse), why AGI will just…
OpenAI's Curvy Road to AGI Includes… Erotica??
OpenAI's ChatGPT will soon allow *adult* AI conversations. What happens next? For now, we get Sora 2 updates and Google ussing AI for actual science, making pro…
Maybe AI Will Cure Cancer After All
Today on the AI Daily Brief, Google may have just shown us how AI can actually help cure cancer. We break down a groundbreaking new discovery from Google and Ya…
October 16, 2025
Why RL Won — Kyle Corbitt, OpenPipe (acq. CoreWeave)
In this deep dive with Kyle Corbitt, co-founder and CEO of OpenPipe (recently acquired by CoreWeave), we explore the evolution of fine-tuning in the age of AI a…
#294 Bhaskar Roy: How Workato Is Building the Rise of the Agentic Enterprise
Try OCI for free at http://oracle.com/eyeonai This episode is sponsored by Oracle. OCI is the next-generation cloud designed for every workload – where you can…
1929 vs 2025: Andrew Ross Sorkin on Crashes, Bubbles & Lessons Learned
(0:00) Chamath and Friedberg welcome Andrew Ross Sorkin to discuss his new book, "1929: Inside the Greatest Crash in Wall Street History--and How It Shattered a…
October 15, 2025
The Problem with ChatGPT Erotica
OpenAI will soon let verified adults access mature content in ChatGPT—including erotica and customizable personalities—under its new “treat adults like adults”…
How Agentic AI Shortens Drug Development and Boosts Patient Outcomes - Ep. 277
Learn how agentic AI is transforming pharma. IQVIA’s Raja Shankar and Avinob Roy share how intelligent automation accelerates clinical trials, improves commerci…
Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell
With demand from AI for energy already exploding, our electric grid is facing a crisis. Base Power CEO and co-founder Zach Dell is ready to re-architect its fut…
How Orlando Bravo Built One of the Most Successful Firms in Private Equity
(0:00) Introducing Orlando Bravo (1:53) Orlando's history, Puerto Rico origins, how he got into private equity (7:10) How he runs Thoma Bravo: small team, outwa…
Rethinking How Life Sciences Organizations Approach AI - Mathias Cousin of Deloitte
Today's guest is Mathias Cousin, Managing Director at Deloitte. With extensive experience in R&D transformation and regulated industry data strategy, Mathias jo…
October 14, 2025
The Next AI Platform Isn't a Model -- It's Your Context
Today on the AI Daily Brief, we explore why the next great AI platform war isn’t about models at all—but about context: who owns it, how it’s organized, and whi…
Bryan Johnson: The #1 Longevity Secret You Can Start Doing Today
(0:00) Introducing Bryan Johnson (0:46) Bryan takes the audience through a quick biological age test (5:53) The single best longevity hack from all of his resea…
#483 – Julia Shaw: Criminal Psychology of Murder, Serial Killers, Memory & Sex
Julia Shaw is a criminal psychologist and author who in her books explores human nature, including psychopathy, violent crime, the psychology of evil, police in…
Streamlining Fund Compliance with AI-Ready Data - Sandro Venturini of UBS
Today's guest is Sandro Venturini, Executive Director and Consultant at UBS. Specializing in cross-border fund structuring and regulatory strategy, he holds yea…
Cathie Wood on How AI Can Double GDP, Bull Case for Bitcoin $1M, Elon's Trillion-Dollar Pay Package
(0:00) Introducing Cathie Wood (0:47) Cathie Wood on AI's once in a lifetime opportunity: doubling GDP, deflation, and more (9:23) Cathie's bull case for Bitcoi…
October 13, 2025
These Are the Jobs People Actually WANT AI to Automate
Today on The AI Daily Brief, Nathaniel Whittemore explores new research revealing which jobs people actually want AI to automate—and which they find morally off…
#293 Greg Shewmaker: How Enterprises Can Implement and Scale with Agentic AI
This episode is sponsored by AGNTCY. Unlock agents at scale with an open Internet of Agents. Visit https://agntcy.org/ and add your support. How can enterprises…
From Tool Sprawl to Defensible Value in AI for Legal - with Christo Siebrits of AbbVie
Today's guest is Christo Siebrits, Senior Associate and General Counsel at AbbVie. With over 20 years of experience in global pharmaceutical legal and complianc…
October 12, 2025
October 10, 2025
Why the Future of AI Has a Body
This episode explores why the next era of artificial intelligence will take physical form. It examines the rise of humanoid robots, breakthroughs in embodied AI…
Trump Brokers Gaza Peace Deal, National Guard in Chicago, OpenAI/AMD, AI Roundtripping, Gold Rally
(0:00) Bestie intros: Welcome back Brad Gerstner! (2:48) Israel-Hamas ceasefire, how Trump and his team got the deal done (13:27) National Guard sent to Chicago…
The Trillion Dollar AI Software Development Stack
AI coding has emerged as a major market for AI: one that’s already rewriting how software gets built.a16z Infra Partners Yoko Li and Guido Appenzeller break dow…
Nick Lane – Life as we know it is chemically inevitable
Nick Lane has some pretty wild ideas about the evolution of life.He thinks early life was continuous with the spontaneous chemistry of undersea hydrothermal ven…