Latest episodes 5,561 total
March 4, 2025
March 2, 2025
March 1, 2025
Sakana AI - Chris Lu, Robert Tjarko Lange, Cong Lu
We speak with Sakana AI, who are building nature-inspired methods that could fundamentally transform how we develop AI systems.The guests include Chris Lu, a re…
What GPT-4.5 Should Be Used For
OpenAI has officially launched GPT-4.5, but it’s not the model most people expected. While it lags behind reasoning focused models like O1 and DeepSeek, it shin…
Epstein Files Flop, State of the Market, Autonomous Robots, Trump's Gold Card, Friedberg on Jeopardy
(0:00) Bestie intros (1:41) Epstein files first release underwhelms (4:40) Friedberg recaps his experience on Celebrity Jeopardy! (14:22) State of autonomous ro…
February 28, 2025
Open Operator, Serverless Browsers and the Future of Computer-Using Agents
Today's episode is with Paul Klein, founder of Browserbase. We talked about building browser infrastructure for AI agents, the future of agent authentication, a…
What DeepSeek Means for Cybersecurity
In this episode of AI + a16z, a trio of security experts join a16z partner Joel de la Garza to discuss the security implications of the DeepSeek reasoning model…
Why AI Compute Consumption Isn't Slowing Down
Despite reports of Microsoft canceling data center leases, AI compute demand is still accelerating. This episode breaks down Wall Street’s ongoing AI skepticism…
February 27, 2025
Telenor's Kaaren Hilsen on Launching Norway’s First AI Factory - Ep. 247
Telenor’s Chief Innovation Officer and Head of the AI Factory, Kaaren Hilsen, discusses Norway’s first AI factory. Opened in November, the facility processes se…
Amazon's New Alexa AI, OpenAI's GPT 4.5, Claude Sonnet's Coding Power & More AI News
Amazon announces a huge AI-powered upgrade called Alexa+, Anthropic's Claude Sonnet 3.7 is amazing at code, OpenAI's GPT-4.5 is on the way, & good lord who let…
Building the Platform for Scientific Breakthrough, with Noubar Afeyan of Moderna and Flagship Pioneering
This week on No Priors, Sarah sits down with Noubar Afeyan, Co-founder and CEO of Flagship Pioneering, the biotech firm behind groundbreaking companies like Mod…
Faster/Slower: Where AI Is Moving Ahead of Expectations and Where its Lagging
To many, it feels like a moment of significant acceleration. We're getting a new model every few days, major advances in agents, and generally there's a…
February 26, 2025
#239 Tuhin Srivatsa: How Baseten is Disrupting AI Deployment & Scaling in 2025
This episode is sponsored by Thuma. Thuma is a modern design company that specializes in timeless home essentials that are mindfully made with premium materials…
Understanding AI's Expanding Role in Drug Discovery and Life Sciences R&D - Liran Belenzon of BenchSci
Today's guest is Liran Belenzon, Co-founder and CEO of BenchSci. BenchSci is a global leader in AI solutions for preclinical R&D that helps decipher complex bio…
First Reactions: Claude 3.7 Sonnet and Claude Code
Claude 3.7 Sonnet has launched to much fanfare. Along with it comes Claude Code, reinforcing just how much Anthropic has found Claude's core use case in cod…
February 25, 2025
Neurobiological and Cybernetic AI for Manufacturing, Part 1 - with Oleg Savin of Unilever
Today's guest is Oleg Savin, Enterprise Architect and MES Expert at Unilever. Oleg is a frequent guest speaker at manufacturing conferences worldwide, including…
Virtual Cell Models, Tahoe-100 and Data for AI-in-Bio with Vevo Therapeutics and the Arc Institute
On this week’s episode of No Priors, Sarah Guo is joined by leading members of the teams at Vevo Therapeutics and the Arc Institute – Nima Alidoust, CEO/Co-Foun…
February 24, 2025
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February 22, 2025
February 21, 2025
The Stablecoin Future, Milei's Memecoin, DOGE for the DoD, Grok 3, Why Stripe Stays Private
(0:00) The Besties welcome John and Patrick Collison! (4:28) Stripe's business evolution: $1T in volume/year, stablecoins, challenging the Visa/Mastercard duopo…
Agents, Lawyers, and LLMs
In this episode of AI + a16z, Aatish Nayak, head of product at Harvey, sits down with a16z partner Kimberly Tan to share his experience building AI products for…
Why Microsoft's CEO Doesn't Believe in AGI
At least...not in the same way others think of it. Microsoft CEO Satya Nadella just sat down for a rare in-depth interview, sharing his thoughts on AGI, Microso…
February 20, 2025
#238 Dominic Williams Reveals His Vision for the Internet Computer (ICP)
This episode is sponsored by Indeed. Stop struggling to get your job post seen on other job sites. Indeed's Sponsored Jobs help you stand out and hire fast. Wit…
xAI's Grok 3 Just Changed The AI Race, Mircosoft's New AI Gaming Model, Spicy ChatGPT And More AI News
AI NEWS: xAI's Grok 3 is good. What does that mean for the future of AI? Plus, OpenAI's spicy update, Convergence's Free-to-use Proxy AI Agent & Microsoft's new…
Building Hard Tech in Hard Markets: Kyle Vogt on Cruise, Twitch, and The Bot Company
Kyle Vogt joins Sarah and Elad on this week’s episode of No Priors. A serial entrepreneur, Kyle co-founded Twitch, transforming live streaming, and later Cruise…
The Advantages of Agentic Process Automation in Financial Services - with Ken Mertzel of Automation Anywhere
Today's guest is Ken Mertzel, Global Industry Leader in Financial Services at Automation Anywhere. Automation Anywhere is a global software company that develop…
What AI Coding Agents Can Do Right Now
AI coding tools are advancing rapidly, but how effective are they for freelance jobs? OpenAI's new SWE Lancer benchmark evaluated top AI models on 1,400 sof…
February 19, 2025
Clement Bonnet - Can Latent Program Networks Solve Abstract Reasoning?
Clement Bonnet discusses his novel approach to the ARC (Abstraction and Reasoning Corpus) challenge. Unlike approaches that rely on fine-tuning LLMs or generati…
Satya Nadella — Microsoft’s AGI plan & quantum breakthrough
Satya Nadella on: Why he doesn’t believe in AGI but does believe in 10% economic growth; Microsoft’s new topological qubit breakthrough and gaming world models…