No Priors: Artificial Intelligence | Technology | Startups
Episodes 183 total
The Changing Physics of Cybersecurity and Drug Development with OpenAI President Greg Brockman
Technology has always been the fundamental driver of improvement for human quality of life. And with the recent rollout of advanced frontier models, like OpenAI…
Beam: The Great American Open Model with ReflectionAI Co-Founder and CEO Misha Laskin
Is the future of frontier AI open or closed? ReflectionAI co-founder and CEO Misha Laskin joins Sarah Guo and Elad Gil to discuss the launch of Beam, the compan…
Frontier Chips for Frontier AI Labs, with Walter Goodwin, Founder/CEO of Fractile
Founder and CEO of full-stack AI chip company Fractile, Walter Goodwin, joins Sarah Guo to discuss the bets he’s made on the future of the chip market as other…
Re-Founding Incumbents for the AI Era with Sequence Holdings Co-Founder and CEO Michael Lee
Can AI transform legacy incumbents rather than replacing them? Sequence Holdings co-founder and CEO Michael Lee joins Sarah Guo to discuss how holding company s…
Why Diffusion Will Win AI Inference with Inception Co-Founder and CEO Stefano Ermon
As generative AI hits hardware and latency bottlenecks, Stanford professor, diffusion pioneer, and Inception co-founder and CEO Stefano Ermon is betting on a ra…
Coinbase’s Everything Exchange: Agentic Finance, Stablecoins, and Tokenization with CEO Brian Armstrong
From the tokenization of real-world assets to funding research on anti-aging therapeutics, Coinbase co-founder and CEO Brian Armstrong is focused on solving met…
Redefining Chip Architecture with Arm CEO Rene Haas
From data center orchestrators to AGI and robotics, CPUs remain the heart of modern computing. Arm CEO Rene Haas joins Elad Gil and Sarah Guo to explore how Arm…
Rethinking Legacy Data Infrastructure with Eon Co-Founders Ofir Ehrlich and Gonen Stein
Google’s purchase of Spirit Airlines’ data out of bankruptcy signaled a shift in how the tech world values real-world datasets. Although compute and models get…
From Restoring Sight to Reimagining the Brain, with Max Hodak
Max Hodak, co-founder and CEO of Science Corporation, joins Sarah Guo to discuss the future of vision, brain-computer interfaces, and the human experience. Max…
What Chess.com Teaches US About Superhuman Capabilities, with CEO Erik Allebest
In a world of infinite gaming and entertainment possibilities, how does a centuries-old game stay so popular? Chess.com co-founder and CEO Erik Allebest joins S…
Chasing Trillion-Dollar Companies, Founder Ambition, Token Budgets, and Regulatory Capture with Sarah & Elad
Is the tech industry moving too quickly, or are founders letting fear of AI labs stunt their ambitions? Sarah and Elad explore the current landscape of artifici…
Building an Autonomous Enterprise for Real-World Services with Netic Founder Melisa Tokmak
When your AC fails in a heatwave, you don’t want a busy signal; you need a solution. Netic founder and CEO Melisa Tokmak joins host Elad Gil to explain how Neti…
Building an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley Tang
DoorDash is not just a delivery company. From its inception, co-founders Andy Fang and Stanley Tang operated it as a robotics and autonomy company. Andy and Sta…
Travel Through the Lens of AI with with Booking.com CEO Glenn Fogel
When Glenn Fogel joined Priceline in 2000, the business was worth a few hundred million dollars. One week later, the Nasdaq peaked, eventually sending its stock…
How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
While the rest of the nuclear industry still relies on simulations and paper designs, Valar Atomics is busy splitting atoms. In fact, they just powered an NVIDI…
Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown
When a new AI model drops, it’s judged based on a static benchmark grid that doesn’t account for how long the model is allowed to think. How then should we meas…
Re-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu Tan
At 66 years old, instead of heading towards retirement, former Cadence CEO and legendary investor Lip-Bu Tan decided to take on the hardest job in tech: turning…
Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
Biohub started with an ambitious goal of curing, preventing, and managing all disease by the end of the century. A decade later, thanks to the convergence of fr…
We Need An Ecosystem in AI, And Every Company Can Win A Place In It
What does it mean for a business to truly operate at the AI frontier? In a special crossover episode at Microsoft Build, Sarah Guo and Elad Gil team up with Lat…
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
We are now closer than ever before to living in a world where AI agents are smart enough to run our power grids and manage water supplies. How do we keep them f…