Latest episodes 5,558 total
March 16
A Guy Used AI to Cure His Dog's Cancer*
The AI discourse is absolutely frenetic right now — everything from Karpathy's misinterpreted jobs visualization to a viral dog cancer cure story that's…
Why Supply Chain Design Becomes the Differentiator as AI Automates Planning - with Don Hicks of Optilogic
The traditional focus on supply chain efficiency has created brittle networks that break under modern volatility and shifting global trade consensus. Optilogic…
#237 - Nemotron 3 Super, xAI reborn, Anthropic Lawsuit, Research!!!
Our 237th episode with a summary and discussion of last week's big AI news!Recorded on 03/13/2026Hosted by Andrey Kurenkov and Jeremie HarrisFeel free to email…
March 15
March 14
March 13
When AI Discovers The Next Transformer - Robert Lange (Sakana)
Robert Lange, founding researcher at Sakana AI, joins Tim to discuss *Shinka Evolve* — a framework that combines LLMs with evolutionary algorithms to do open-en…
Pro-Worker AI
A growing debate is emerging around how AI can expand human work instead of replacing it. This episode looks at the idea of “pro-worker AI,” the kinds of tools…
Iran War, Oil Shock, Off Ramps, AI's Revenue Explosion and PR Nightmare
(0:00) The Besties welcome Brad Gerstner! (3:48) Economic fallout of the Iran War, escalation scenarios, impact on midterms (19:18) Off ramp strategies, Gulf st…
Dylan Patel — Deep dive on the 3 big bottlenecks to scaling AI compute
Dylan Patel, founder of SemiAnalysis, provides a deep dive into the 3 big bottlenecks to scaling AI compute: logic, memory, and power.And walks through the econ…
AI Can Improve Itself Now. We're Sure That's Fine.
AI just learned how to make itself smarter. That's not a hypothetical anymore. Recursive self-learning is here, and it's changing everything about how AI develo…
Turning Market Shifts into Field Action for Medtech Commercial Teams - with Mike Monovoukas & Alex Wakefield of AcuityMD
The reliance on historical data and manual CRM entry has created a significant gap between internal strategy and the real-time signals driving today's complex m…
March 12
Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
Turbopuffer came out of a reading app.In 2022, Simon was helping his friends at Readwise scale their infra for a highly requested feature: article recommendatio…
What Vibe Coding is Turning Into
New products from Perplexity and Replit show vibe coding evolving beyond “AI helps you code” into systems that plan goals, spin up teams of agents, and execute…
#236 - GPT 5.4, Gemini 3.1 Flash Lite, Supply Chain Risk
Our 236th episode with a summary and discussion of last week's big AI news!Recorded on 03/06/2026Hosted by Andrey Kurenkov and Jeremie HarrisFeel free to email…
Building AI Factories: How Red Hat and NVIDIA Turn Enterprise Data Into Intelligence - Ep. 293
Enterprises are moving from AI pilots to full‑scale AI factories that turn data into trusted digital intelligence. Red Hat CTO Chris Wright and NVIDIA’s Justin…
From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
Notion isn’t designing AI agents that just use tools. Their agents can autonomously build their own integrations, as well as write the code needed to finish a t…
Why Manual K-1 Workflows Are Breaking Under Modern Tax Complexity - with Ken Powell of K1x
In today's episode sponsored by K1x, the accounting sector faces a critical inflection point as a deficit of 300,000 professionals intersects with escalating re…
March 11
Why Google Workspace CLI is a Big Deal
Google has been shipping relentlessly across Gemini models, world models, multimodal tools, and Workspace updates, but the release getting the most attention fr…
#493 – Jeff Kaplan: World of Warcraft, Overwatch, Blizzard, and Future of Gaming
Jeff Kaplan is a legendary Blizzard game designer of World of Warcraft and Overwatch, now preparing to launch a new game, The Legend of California, from his new…
#326 Zuzanna Stamirowska: Inside Pathway's Post-Transformer Architecture Designed for Memory and On-the-Fly Learning
This episode is sponsored by tastytrade. Trade stocks, options, futures, and crypto in one platform with low commissions and zero commission on stocks and crypt…
Rewriting the Rules: The SEC & CFTC on Crypto, IPOs & the Future of American Markets
(0:00) Jason and Chamath welcome SEC's Paul Atkins and CFTC's Michael Selig (0:53) Atkins on how US markets have changed over his 40 year career (3:04) Top prio…
The most important question nobody's asking about AI
Read the full essay here: https://www.dwarkesh.com/p/dow-anthropicTimestamps(00:00:00) - Anthropic vs The Pentagon(00:04:16) - The overhangs of tyranny(00:05:54…
Building a Virtuous Cycle of Analytics in Global Enterprises - with Barry McCardel of Hex
Enterprise data estates often optimize for platform expansion over decision velocity, producing reporting layers that signal activity but fail to accelerate str…
March 10
The Debate Over Anthropic’s New Product: Price or Existential Dread?
Claude’s new AI code review feature sparked a huge backlash this week, with developers stunned by the $15–$25 per pull request pricing. But the debate quickly b…
Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI
Jack Neel speaks with Amjad Masad, CEO at Replit, about how AI is making it easier than ever to build and ship software without a technical background. They dis…
NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)
Join Kyle, Nader, Vibhu, and swyx live at NVIDIA GTC next week!Now that AIE Europe tix are ~sold out, our attention turns to Miami and World’s Fair!The definiti…
AI Use Cases, Deployment, and Measuring Real-World ROI - with Ylan Kazi of Blue Cross Blue Shield of North Dakota
Today's guest is Ylan Kazi, Chief Data and AI Officer at Blue Cross Blue Shield of North Dakota. With deep experience leading enterprise AI strategy in regulate…
March 9
Graham Allison on the Global Realignment: Iran, China, Israel, Greenland
(0:00) The Besties welcome legendary Harvard professor Graham Allison (1:14) Iran Conflict: Strategy, Netanyahu's influence, Trump's motivation, redefining Midd…
Autoresearch, Agent Loops and the Future of Work
Andrej Karpathy released autoresearch this weekend — a system where an AI agent runs experiments to improve a language model overnight, keeping what works and d…
#325 Phelim Brady: Why AI's Future Depends on Human Judgement
AI often looks fully automated. But behind the scenes, a huge amount of human judgment is shaping how these systems actually work. In this episode, Craig Smith…