Latent Space: The AI Engineer Podcast
Episodes 235 total
Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio
A few years ago I stumbled upon Leash Bio’s Substack, and was hooked. Be it their Kaggle competition that showed that no, we really haven’t solved protein-ligan…
Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics
Watch along AIE NYC and join us at AIE CODE in SF next month!This episode includes a live demo of the Taku robot that is best enjoyed on YouTube.Last month, Dyn…
Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub
From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding, Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what…
Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk
It’s hard to believe that Periodic was only launched last September:One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying tal…
Academia is for Ambition — Alex Zhang, MIT
Last call for regular tickets for AI Engineer NYC! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for n…
Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week
Three months ago Dwarkesh, who has been posting incredible blogs and episodes about RL, posted a framing question for his video essay on RLVR which upset a lot…
Claude Code’s Next Era — Thariq Shihipar, Anthropic
We are excited to have Anthropic share their latest AI x Finance work at AI Engineer New York, coming up in 2 weeks!In case you’ve been under a rock, here’s a n…
OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha
From the earliest days of open-weight models to becoming the neutral routing layer for more than 10 million developers, OpenRouter is one of the clearest bets t…
Runway’s WorldPrompt and the Engineering of Real-Time Worlds
Earlier this month, world model company Runway introduced GWM Worlds 2, a research preview that “turns high-fidelity video and audio generation into real-time i…
🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)
The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. T…
🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science
How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar, two textbo…
Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI
Tickets for AIE NYC now open, and apply for the invite-only AIE CODE. Join us!We have an unusual relationship with today’s guest: for years since coauthoring th…
Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC
AIUC first got our attention with the NFDG backing, and have just announced a $40M series A today, with the most impressive industry advisor list we may have ev…
Humanity’s Last Invention — Richard Socher of Recursive
At 1:09:00 we talk about the rise of AI x Finance, and AIE NYC is one month away - our hotel block is 97% sold out, get tix & travel ASAP - we will announce spe…
🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing
A few years ago, Caltech Prof. and co-founder of Accelerated Understanding, Anima Anandkumar set out to develop the first open-source weather model with AI. Tal…
Simulation: the new Scaling Law — Joon Sung Park, Simile AI
When we first dicsussed the Summer of Simulative AI in 2024 we knew it would be a brief summer, but it has recently come back with a vengeance with SimGym in Ap…
🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
This January, four big AI × Pharma tools deals were announced at the huge JPM Pharma conference that takes over San Francisco every year. OpenAI-backed Chai Dis…
The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
Watch the full episode on YouTube:We first covered Baseten last year when DeepSeek mania was at peak hype. Now they have raised a monster $13B round and become…
Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
There are roughly 100x more people who use code than who can write code. As code that “just works” becomes easier to generate, this group may be the biggest pri…
Inside the Model Factory — Eiso Kant, Poolside AI
In recent months, the open vs closed, and US vs China discussions on model ownership and sovereign/local AI have heated up to a fever pitch. So it is very very…